Kinetics of Antimicrobial Action

Surfacine acts upon contact with the microorganisms, intercalating into the bacterial membranes and transferring a broad spectrum antimicrobial agent directly to the contacting organism.

Tubes with various diameters were inoculated with initial concentrations of up to 109 CFU/mL of Pseudomonas aeruginosa (ATCC#9027) and incubated at 30°C. At various time points, tubes were sampled and the microorganisms were plated and counted. Surfacine treated tubes demonstrate high antibacterial activity even when volume to surface ratios exceed 1:4 (see figure below).